As the most advanced form of IV ozone therapy, EBOO is particularly beneficial for individuals with:

• Chronic illnesses such as chronic fatigue, autoimmune disease, fibromyalgia, diabetes, hepatitis, etc.

• Long Covid-19 and vaccine related injuries

• Cardiovascular conditions – cholesterol disorders, hypertension, cardiovascular disease, peripheral arterial disease.

• Acute and chronic infections – herpes, Lyme disease, EBV, shingles

• Neurological conditions – Parkinson’s disease, dementia, neuropathy

• Inflammatory conditions, chronic pain, and fibromyalgia

• Gastrointestinal conditions – Crohn’s disease, colitis, Celiac disease

• Vaccine injuries

Also a great treatment for individuals seeking:

• Improved energy and vitality

• Stronger immune system and overall wellness enhancement

• Superior athletic recovery and performance

• Patients undergoing detoxification therapies

The EBOO filtration is essential to cleansing your blood of physical debris that neither the kidneys, nor liver, are capable of removing. The purified, debris-free blood is then re-infused back into the patient.

EBOO appears to remove the following from the body:

• Covid-19 spike protein and associated toxin-like peptides

• Heavy Metals – lead, mercury, cadmium, arsenic, etc.

• Extracellular inflammatory fluid

• Endotoxins – which are fragments of pathogenic bacteria, fungus and mold infections that have been killed.

• Biofilms – which is a kind of protective layer that many pathogenic microbes create to hide behind and where our immune cells can not penetrate.

• Debris from our own tissues that have been damaged from the infecting microbes and/or from powerful antimicrobial pharmaceutical drugs.

• Micro clots – microscopic blood clots that are resistant to the body’s own fibrinolytic processes.

• Fungi

• Residuals for medications

• Environmental and industrial toxins – pesticides etc.

• Chemotherapy

• Excessive and/or abnormal blood clotting

• Other impurities

EBOO is an advanced physician-directed medical therapy—not simply an IV treatment. Because it directly interacts with your bloodstream and can influence multiple physiologic systems, it should be prescribed and supervised by a qualified physician who understands your medical history and treatment goals.

Before beginning EBOO, you’ll first establish care with one of our physicians. During this evaluation, we review your medical history, current medications, health conditions, previous treatments, and any relevant laboratory testing. This allows us to determine whether EBOO is appropriate for you, identify any precautions or contraindications, and customize the treatment to maximize both safety and therapeutic benefit.

No two patients are alike. Factors such as your diagnosis, overall health, hydration status, nutritional status, medications, cardiovascular health, laboratory findings, and treatment goals can all influence how EBOO should be performed. In some cases, we may recommend addressing nutritional deficiencies, supporting detoxification pathways, treating underlying infections, or implementing other therapies before beginning EBOO to help optimize your response.

At Aspen Integrative Medical Center, we believe EBOO works best when it is integrated into a comprehensive medical treatment plan rather than performed as a stand-alone therapy. Our physicians continually monitor your progress, adjust your treatment plan as needed, and combine EBOO with other evidence-informed therapies when appropriate to help you achieve the best possible outcomes.

Our commitment is to provide thoughtful, individualized medical care that prioritizes both your safety and your long-term health—not simply administering a procedure.

At your establishing care appointment with Dr. Despres, he will review all required and recommended lab work to be completed prior to starting EBOO. At a minimum, the following labs are needed within 4–6 weeks of beginning treatment: complete blood count (CBC), comprehensive metabolic panel (CMP), iron/TIBC, ferritin, and glucose-6-phosphate dehydrogenase (G6PD) quantitative.

Dr. Despres may also order additional tests—such as inflammatory markers (CRP, ESR, MPO), oxidative stress markers (LDH, GGT), infectious disease screening, or heavy metal testing—to gain a more complete understanding of your health and monitor progress throughout treatment.

Please note: Patients are welcome to complete a CBC, CMP, G6PD, ferritin, and iron/TIBC through another provider prior to their establishing care appointment. However, our clinic does not provide lab orders in advance, as lab testing is discussed and prescribed during your appointment with Dr. Despres.

Yes, this is especially helpful if you’re not local, live out of state, and/or plan to visit Flagstaff for a limited time. In this case, you would begin with a 60-minute virtual establishing care appointment with Dr. Despres. During this visit, he will prescribe a personalized EBOO treatment plan, order any necessary lab work, and recommend other naturopathic therapies to support your health goals. Once your labs are completed and reviewed by Dr. Despres, you’ll be able to begin EBOO treatment when you are in town.

Please note: Having easily accessible veins is important for EBOO treatment and will be discussed during your appointment. While our team is highly trained in IV therapy and skilled in catheter placement, we cannot guarantee successful line placement in every case. We do use ultrasound guidance as needed for more challenging placements.

The patient arrives for their appointment just as they would for any other IV treatment. The procedure itself is similar to dialysis: blood is withdrawn from a vein by a pump, passes through a specialized filter where it is enriched with an oxygen-ozone gas mixture, and is then reintroduced into the body through a different vein in the other arm. This filtration process removes debris from destroyed pathogens, heavy metals, fungi, and other impurities while ozonating the blood in stages. The filtration is essential to cleansing your blood of physical debris that neither the kidneys, nor liver, are capable of removing.

Because EBOO is a closed system, the blood is never exposed to outside elements, eliminating the risk of contamination. The entire treatment—including catheter placement, therapy administration, and completion—typically takes 60 to 120 minutes. For patients with difficult-to-access veins, ultrasound guidance is used to ensure safe and effective catheter placement.

Most patients find the procedure comfortable, with minimal discomfort. Some may experience a slight tingling sensation during treatment, but these effects are generally mild and temporary.

We recommend the following for the best results, but not required:

• Hydrate: Be sure you are well hydrated (drink at least 32 oz of water in the 24 hours prior to your treatment)

• Eat Well: Eat a meal high in protein and healthy fats within 2 hours prior to your treatment. Limit/remove any highly processed or sugary foods.

• Avoid Supplements: Avoid taking any vitamins or minerals within 2 hours prior to your treatment.

• Attire: Wear a short sleeve shirt that provides easy access to both arms for placing the IV line.

• Rested: Do your best to come relaxed, low stress, and well-rested.

• Notification of Changes: Inform our office of any new or acute health concerns, medications, reactions, or general concerns since your last visit.

• Give Feedback: Your feedback between procedures is crucial for providing tailored and relevant treatment. Plan to share your feedback at each visit or over the phone prior to your next treatment

Yes, EBOO can be your first ozone treatment, and many patients are able to complete a full EBOO session on their first visit. However, Dr. Despres will first review your full medical history and recent lab work to determine if EBOO is the most appropriate starting point for you. In some cases, he may recommend beginning with Hemealumen IV ozone therapy to assess how your body responds to ozone overall. When it’s time to begin EBOO, you will be closely monitored and guided on how to minimize any potential healing reactions afterward.

The degree of side effects varies depending on the patient’s individual health, the dose of ozone administered, and the severity of their condition. For example, patients with long-standing chronic illnesses like Long COVID or Lyme disease may experience a “healing reaction” (also known as a Herxheimer reaction or “herx”). This occurs when the immune system is stimulated, detox pathways are activated, and infections begin to die off. As a result, some patients may feel more fatigued immediately after treatment as the body prioritizes healing and recovery.